Tawaga daga Cibiyar Haihuwa ta Jami'ar Columbia ta cimma nasarar ciki na farko ta hanyar tsarin hankali na wucin gadi An ƙera shi don dawo da maniyyi a lokuta na azoospermia, yanayin da maniyyi ba ya nuna alamun haifuwa na namiji. Babban ci gaba, wanda aka kwatanta a cikin wasiƙar bincike a cikin The Lancet, yana wakiltar gagarumin ci gaba a cikin maganin haihuwa kuma a cikin shirin ciki da kuma magance rashin haihuwa namiji.
A cikin wannan mahallin, abubuwan maza suna cikin kusan 40% na ma'aurata rashin haihuwaKuma tsakanin kashi 10 zuwa 15% na maza marasa haihuwa suna da azoospermia. Ko da yake samfurin na iya bayyana al'ada, duban kusa sau da yawa yana nuna ba a iya gane maniyyi; kamar yadda darektan cibiyar, Zev Williams, ya taƙaita, da yawa ma'aurata suna shirin daukar ciki An gaya musu cewa zaɓin ilimin halittar su yana da iyaka sosai, wani abu da wannan ci gaba zai iya sake tunani.
Yadda hanyar STAR ke aiki
Don magance wannan ƙalubale, ƙungiyar ta haɓaka STAR (Sperm Tracking and Recovery), hanya da ke haɗawa hangen nesa na kwamfuta, microfluidics, da madaidaicin robotics don ganowa da ceton maniyyin da ba kasafai ba ba tare da lalata su ba.
Tsarin yana ɗaukar miliyoyin hotuna masu girma na samfurin a cikin ɗan gajeren lokaci; AI yana gano yuwuwar maniyyi, guntu tare da tashoshi microfluidic yana jagorantar sashin sha'awa, kuma a cikin al'amarin milliseconds, robot A hankali yana fitar da tantanin halitta da aka zaɓa don amfani da shi a cikin hadi na in vitro ko don adanawa.
Lamarin da ya haifar da bege
An gwada hanyar a kan majiyyaci wanda abokin tarayya ke sanye da na'urar hana haihuwa. kusan shekaru ashirin suna ƙoƙari don samun yara, bayan gazawar IVF da yawa da kuma tiyata guda biyu da ba su yi nasara ba. Har sai lokacin, hanyoyin sun tabbatar da rashin nasara kuma tare da illa masu illa.
Daga samfurin milliliters 3,5, STAR yayi nazari kusan Hotuna miliyan 2,5 a cikin kimanin sa'o'i biyu da kuma gano maniyyi guda biyu masu dacewa. An yi amfani da waÉ—annan sel guda biyu don haifar da amfrayo guda biyu, kuma É—aya daga cikinsu ya haifar da a ciki mai gudana, Tunawa da ka'idar asibiti cewa kwayar lafiya guda É—aya ta isa don fara ci gaban amfrayo.
Me ke canzawa ga rashin haihuwa na namiji
Alkaluman sun sanya matsalar cikin hangen nesa: dalilin namiji yana da hannu a cikin kashi 40% na matsalolin rashin haihuwa, kuma a cikin waÉ—annan, Azospermia yana cikin kashi 10-15% na maza tare da matsalolin haihuwa. Har ya zuwa yanzu, yawancin marasa lafiya sun dogara da cirewar tiyata kai tsaye daga cikin gwano ko dogon binciken hannu a cikin dakin gwaje-gwaje.
Duk hanyoyin biyu suna da iyakancewa: hanyoyin tiyata sune cin zali Sau da yawa sukan kasa dawo da sel masu aiki, tare da haɗari irin su kumburi, sauye-sauye na jijiyoyin jini, ko raguwa na wucin gadi a cikin testosterone; a halin da ake ciki, sikanin da hannu ya ƙunshi dogon lokaci, tsada mai tsada, da magudi wanda zai iya daidaita yiwuwa na maniyyi.
Hanyar sarrafa kai ta STAR tana magance waɗannan ƙullun ta hanyar haɗa saurin ganowa da kuma keɓe kai tsaye, wanda zai iya rage amfani da fasahohi masu tsauri da ƙara yuwuwar gano hakan. maniyyi maniyyi lokacin da adadin su yayi ƙasa sosai.
Matakai na gaba da yiwuwar tasiri a Turai
Kodayake wannan lamari ne na farko, ƙungiyar Columbia ta nuna cewa suna kan aiki manyan gwaje-gwaje na asibiti don kimanta tasiri da sake fasalin hanyar a cikin mutane daban-daban. Wannan tsari zai kasance mai mahimmanci wajen tantance ci gaba da haɗa shi azaman daidaitaccen kayan aiki a cikin asibitocin haihuwa.
Idan an tabbatar da aikinta, cibiyoyin Turai da Mutanen Espanya na iya sha'awar haɗawa da mafita iri ɗaya, wani abu da zai buƙaci tabbataccen shaida, ingantaccen fasaha da bin ka'idodin ka'idoji na yau da kullun a cikin Tarayyar TuraiMatsakaicin ɗaukar nauyi zai ƙunshi tabbatar da sakamako, ayyana ma'aunin amfani, da tabbatar da cewa ana amfani da fasahar don amfanin majiyyaci kuma tare da ingancin garanti.
Wannan ci gaban ba ya kawar da duk shinge lokaci guda, amma yana buÉ—e hanya mai ma'ana: tsarin tare da AI mai iya gano abin da ba a iya gano shi a bayawanda ya riga ya haifar da ciki kuma, idan bincike ya goyi bayan shi, zai iya canza tsarin azoospermia a cikin shawarwarin haifuwa da aka taimaka.
