Tawagar Magungunan Stanford sun yi nasarar juyar da alamu da yawa masu alaƙa da Autism a cikin beraye. daidaita ayyukan wani takamaiman da'irar kwakwalwa tare da taimakon maganin gwaji da ake amfani da shi don magance farfaɗiya. Binciken ya gano wata maɓalli mai mahimmanci a cikin sarrafa hankali kuma yana danganta shi da halayen halayen rashin lafiyan bakan Autism (ASD).
Marubutan, wanda aka buga sakamakonsu a Kimiyyar Kimiyya, sun nuna cewa dabbobin da aka yi musu magani sun nuna rashin jin daɗi ga abubuwan motsa jiki, raguwa a cikin halaye masu maimaitawa da inganta hulɗar zamantakewa da iya magance cin zarafi, ban da ƙanƙan da kai don kamuwa da cuta. Ko da yake wannan binciken ya ƙunshi nau'ikan dabbobi, yana buɗe hanya mai ban sha'awa don yin nazari.
Abin da ƙungiyar ta gano: Maɓalli mai mahimmanci a cikin "tace" a hankali na kwakwalwa
Aikin yana mai da hankali kan reticular tsakiya na thalamus, yankin da ke aiki azaman tacewa tsakanin thalamus da cortex, yana daidaita kwararar bayanan azanci. A cikin berayen da aka canza zuwa ƙirar ASD (rashin a cikin jigon Cntnap2), an lura da wannan yanki zuwa ya nuna hyperactivity mai alama don motsa jiki kamar haske ko gutsutsun iska da kuma abin mamaki, har ma a yayin mu'amalar zamantakewa.
Bugu da ƙari, an gano masu bincike fashe-fashe na ayyuka na bazata a cikin wannan tsakiya wanda ya haifar da kamawa. Wannan dysregulation yana ba da zaren gama gari: yana iya yin bayani lokaci guda halaye irin na Autism da ƙara haɗarin farfadiya, yanayi guda biyu da ke faruwa sau da yawa a cikin marasa lafiya ɗaya.
Yadda gwajin gwajin yayi aiki da abin da ya canza a cikin mice
Don gwada ko rage wannan wuce gona da iri ya isa don inganta ɗabi'a, ƙungiyar ta gudanar Z944, mai hana tashar calcium tashar T-type a cikin gwajin lokaci na kamewa. Ta hanyar rage haɓakar haɓakar thalamic reticular nucleus, mice Sun dawo da ƙarin tsarin ɗabi'a na yau da kullun.
A cikin layi daya, dabarun neuromodulation da aka sani da JINI, wanda ke ba da damar zaɓin sarrafa ayyukan neuronal ta amfani da masu karɓa da aka tsara da takamaiman kwayoyi. Da wannan fasaha, hana reticular tsakiya ya juyar da kasawar dabbobi tare da samfurin ASD, yayin da ƙara yawan ayyukan su a cikin mice masu lafiya haifar da halayen autism-kamar.
- Ƙarƙashin haɓakar hankali zuwa haske ko tactile stimuli.
- Rage halayen maimaitawa da kuma motsin motsa jiki.
- Haɓakawa a cikin zamantakewa da kuma a cikin mayar da martani ga yanayin zamantakewa.
- Rage yiwuwar kamuwa da cuta.
Wadannan sakamakon sun goyi bayan ra'ayin cewa Hanyoyin ASD da epilepsy sun zo tare a cikin wannan yanki, wanda zai iya bayyana dalilin da ya sa yanayin biyu sukan kasance tare a mafi girma fiye da yawan jama'a.
Tasirin asibiti, iyaka da kuma taka tsantsan
Nazarin ya sanya Thalamic reticular tsakiya a matsayin sabon makasudin warkewa yiwuwar ASD. Marubutan, ciki har da John Huguenard (shugaban marubuci) da Sung-Soo Jang (marubuci na farko), sun jaddada cewa. ba magani bane, amma a maimakon haka hanya ce da ke ba da damar daidaita yanayin da'irar da ke cikin alamun da suka dace.
Yana da mahimmanci a jaddada cewa ƙarshe ya fito daga samfurin dabba, don haka fassararsa ga mutane yana buƙatar gwaji na asibiti wanda ke kimanta inganci da aminci. Ko da tare da wannan taka tsantsan, gaskiyar cewa Z944 yana aiki T-nau'in tashoshi na calcium da kuma cewa fasahar neuromodulation sun tabbatar da rawar da ke haifar da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
Ta fuskar kiwon lafiyar jama'a, kungiyoyi irin su Autism Spain ta kiyasta yawan ASD a kusan 1 cikin kowane yara 100.Rashin jiyya na pharmacological da aka jagoranta a cikin jigon cuta-bayan kulawar alamomi-yana nufin cewa gano takamaiman manufa a cikin kwakwalwa yana da mahimmanci musamman ga ci gaban hanyoyin kwantar da hankali na gaba.
Ayyukan Stanford suna bayarwa tabbataccen hujja na ra'ayi: Rage haɓakar haɓakar "tace" na hankali a cikin kwakwalwa na iya canza mahimman halaye a cikin samfurin autism. Idan babu nazarin ɗan adam, binciken ya dace da sanannen alaƙa tsakanin thalamus, cortex, da farfadiya, da yana buɗe hanyar bincike don ƙarin ingantattun jiyya waɗanda ke daidaita ingantattun hanyoyin da'irar jijiyoyi.
